Not the same: Homogenous means the appearance is all the same, like a bowl of milk is all white or charcoal is all black. The McDonald criteria are used to diagnose MS by incorporating clinical and radiologic evidence of multiple attacks disseminated in space and time (6,9). Cervical (neck) spinal cord T2/FLAIR lesions could cause tingling and numbness in the hands and legs. Figure 12a. However, you may visit "Cookie Settings" to provide a controlled consent. HIV myelopathy. Although quality control and artifact are not the focus of this article, the radiologist should be mindful of the causes of artifact at spinal imaging. In primary HIV-associated myelopathy, patients typically present with progressive spastic paraparesis, ataxia, and loss of sensation. doi: 10.1002/jsp2.1178. So substances with short T2s have smaller signals and appear darker than substances with longer T2 values. Many nerves send electrical signals to and from the brain and spinal cord. Spondylotic compressive changes with myelomalacia. (a) Axial T2-weighted MR image shows hyperintensity in the lateral aspects of the cervical spinal cord (arrows) without enhancement or cord expansion. C5-C6, C6-C7, C7-T1: Canal and foramina remain relatively patent at these levels. It does not store any personal data. Spinal cord herniation in a 66-year-old man with a history of chronic back pain and acute onset of thoracic intrascapular pain. The overall prognosis is worse and the physical manifestations are more severe in patients with NMOSD than in patients with MS (1,6). Join our community today. Recurrent idiopathic TM in a 60-year-old man with several weeks of worsening bilateral lower extremity weakness, pain, and numbness that progressed to an inability to walk. (c) Follow-up axial MR image 6 months later demonstrates complete resolution of the previously seen hyperintense lesion in the right thalamus. Or, maybe make mild stenosis worse due to the increased CSF amount / pressure? Medical researchers are continuously looking into new drug therapies to help regain sensory and motor function. Simple home remedies like an ice bag, heating pad, massage, or a long hot shower can help reduce pain. Figure 15a. The correct thing to do is ask the physician who ordered the MRI to explain the findings to you as that person has all the history and clinical findin Mri of t spine yesterday. The cookie is used to store the user consent for the cookies in the category "Analytics". The term MRI hyperintensity defines how components of the scan look. Nonetheless, imaging of the cord in suspected ALS can help confirm the diagnosis, exclude other causes, and monitor progression (50,51). as a cause for any neurological deficit. 30, No. Connect with a U.S. board-certified doctor by text or video anytime, anywhere. Intramedullary spinal cord abscess is a more serious although rare diagnosis, which has also been reported as being caused by several pathogens. 3. The three signals are: Sensory- signals that evoke feelings like temperature, touch, pain, and pressure. The reason for this is unclear and equally what it means for patients is not clear. 2 What are the symptoms of spinal cord problem? Especially the abnormal signal. A spinal lesion is an abnormal change caused by a disease or injury that affects tissues of the spinal cord. NMOSD in a 36-year-old woman. Had an mri of my cervical spine done. We also use third-party cookies that help us analyze and understand how you use this website. Arachnoid web in a 47-year-old man with a history of progressive paraparesis and lower extremity numbness. T-spine mri findings show "small posterior disc extrusion is noted at superior t6 level with associated ventral cord deformity/minimal impingement." Results: Myelomalacia: Refers to increased T2 signal in the cord, BUT the cord is atrophic and gliotic as a result of a chronic injury of any form and is irreversible and the patient's symptoms will not improve. Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors. When there are multiple lesions or additional lesions in the cerebellum, the diagnosis of von HippelLindau disease should be considered (42,43). The meaning stems from what your symptoms are and what your exam findings are and why you had the MRI in the first place. The purpose of this study was to evaluate the effect of spinal cord T2 signal intensity changes on the outcome . Loss of spinal cord volume can occur for a number of different physical reasons, like falls, athletic trauma or car accidents, but they all result in a similar pathology in the body - a reduction in the blood supply to the spinal cord. They give the actual measurements from front to back (AP) of cord so the degree of compression can be appreciated. By using our website, you consent to our use of cookies. Of particular note, Gibbs artifact can appear as alternating lines of low and high SI extending along the long axis of the spinal cord, which can mimic a cord SI abnormality or a syrinx (3) (Fig 2). Grade 3 denotes increased signal intensity of spinal cord near compressed level on T2-weighted images. Lumbar spine mri shows:" the bone marrow signal is grossly homogeneous.there is no bone marrow edema,there is a left disc herniation." Bethesda, MD 20894, Web Policies Extent of spinal cord compression: the value measured as sagittal diameter of the most compressed spinal cord segment/sagittal diameter of the C1 segment; smaller values indicate more severe . A short T2 means that the signal decays very rapidly. (a) Sagittal T2-weighted MR image demonstrates long-segment hyperintensity (arrows) extending from the upper to mid thoracic cord without expansion. 1, 2023 Radiological Society of North America, Imaging approach to the cord T2 hyperintensity (myelopathy), Magnetic resonance imaging assessment of degenerative cervical myelopathy: a review of structural changes and measurement techniques, Pitfalls and artifacts encountered in clinical MR imaging of the spine, Compressive myelopathy: magnetic resonance imaging findings simulating idiopathic acute transverse myelopathy, Compressive myelopathy mimicking transverse myelitis, Spinal cord MRI in multiple sclerosis: diagnostic, prognostic and clinical value, Temporal trends in the incidence of multiple sclerosis: a systematic review, Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria, Cerebrospinal fluid humoral immunity in the differential diagnosis of multiple sclerosis, Differential diagnosis of T2 hyperintense spinal cord lesions: part B, Grey matter pathology in multiple sclerosis, Acute disseminated encephalomyelitis in childhood: epidemiologic, clinical and laboratory features, Acute disseminated encephalomyelitis: current understanding and controversies, Acute disseminated encephalomyelitis in children: differential diagnosis from multiple sclerosis on the basis of clinical course, Imaging of acute disseminated encephalomyelitis, Spectrum of MRI brain lesion patterns in neuromyelitis optica spectrum disorder: a pictorial review, The incidence and prevalence of neuromyelitis optica: a systematic review, Comparison of clinical characteristics between neuromyelitis optica spectrum disorders with and without spinal cord atrophy, A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis, Cerebrospinal fluid findings in aquaporin-4 antibody positive neuromyelitis optica: results from 211 lumbar punctures, Neuromyelitis optica: clinical features, immunopathogenesis and treatment, Bright spotty lesions on spinal magnetic resonance imaging differentiate neuromyelitis optica from multiple sclerosis, Differentiating neuromyelitis optica from other causes of longitudinally extensive transverse myelitis on spinal magnetic resonance imaging, An approach to the diagnosis of acute transverse myelitis, Acute transverse myelitis: incidence and etiologic considerations, Diagnosis and differential diagnosis of acute transverse myelopathy: the role of neuroradiological investigations and review of the literature, Spinal cord ischemia: practical imaging tips, pearls, and pitfalls, Spinal cord ischemia: clinical and imaging patterns, pathogenesis, and outcomes in 27 patients, Posterior spinal cord infarction due to fibrocartilaginous embolization in a 16-year-old athlete, Spinal cord infarction: clinical and magnetic resonance imaging findings and short term outcome, Imaging Approach to Myelopathy: Acute, Subacute, and Chronic, Neuroimaging in acute transverse myelitis, Spinal cord infection: myelitis and abscess formation, Diffusion-weighted MR imaging of intramedullary spinal cord abscess, Neoplasms of the spinal cord and filum terminale: radiologic-pathologic correlation, Intramedullary Spinal Cord Tumors. These cookies ensure basic functionalities and security features of the website, anonymously. 5 What are symptoms of S1 nerve root damage? 1 What does spinal cord impingement mean? Once artifacts and extrinsic compression are excluded as possible causes of cord SI abnormality, the remaining cord SI alterations can be considered intrinsic to the spinal cord. X-rays may also show an abnormal alignment of your spine. i had spine mri done. This cookie is set by GDPR Cookie Consent plugin. (b) Sagittal CT myelogram demonstrates relative expansion of the cord at the T4 level (arrow) with focal cord thinning at the T3-T4 level (arrowhead), corresponding to the cord abnormality seen on the MR image. It is characterized by loss of motion and sensation in arms and hands. Patients with ventral cord syndrome present with . The three signals are: Sensory- signals that evoke feelings like temperature, touch, pain, and pressure. This pattern is caused by the high-contrast interface of CSF with the spinal cord and can be minimized by increasing the number of phase-encoding steps, switching the frequency- or phase-encoding directions, or decreasing the field of view (3). In the year since the most recent MRI, I have developed new pain recently on top of my normal chronic pain. Estimates for the incidence and prevalence of ventral cord syndrome vary, yet it is the most common type of spinal cord infarction. And surgical outcome in cervical myelopathy have yielded conflicting results syrinx is a group of housed. An increase in T2 signal intensity is often associated with chronic compression of the spinal cord, and it is well established that chronic compression results in structural changes to the spinal cord. Nervous System Includes brain, spinal cord and nerves What does it mean to be brain dead? The back may also be stabilized by fusing some of the vertebrae together. Sciatica from the S1 nerve root occurs as a result of the compression of the nerve between the L5S1 segments of the spinal cord. Axial T2-weighted MR image (a), diffusion-weighted MR image (b), and apparent diffusion coefficient (ADC) map (c) show postoperative changes in the paraspinal soft tissues (arrows in a). (a) Sagittal T2-weighted MR image demonstrates a syrinx extending from C7 to the level of the T2-T3 disk space (arrow) with adjacent cord SI abnormality. General description and important info a. On basic MRI imaging, swelling is not that easy to detect; a doctor may look for a slight enlargement of the spinal cord or some signal change. Many causes of spinal cord compression cant be prevented. Assessment of spinal cord compression by magnetic resonance imaging--can it predict surgical outcomes in degenerative compressive myelopathy? The explanation and descriptions are easy to follow and so helpful in understanding the a variety of conditions covered.Thank you Dr Corenmen for providing such a valuable directory of information. They control function to the body from the shoulders down. By Staff Reporter Last updated Mar 10, 2020 335. These abnormalities appear as characteristic cord contour distortion at imaging. The purpose of this study was to evaluate the effect of spinal cord T2 signal intensity changes on the outcome . Sagittal STIR (a), T1-weighted (b), and contrast-enhanced T1-weighted (c) MR images demonstrate a heterogeneous mildly enhancing intramedullary lesion in the upper thoracic cord, causing cord expansion (arrow). Messages also are carried up the spinal cord to the brain so a person can feel sensations. Normally, MS is a somewhat painless disease with symptoms of paresthesias (pins and needles) and sensory change along with balance issues. There is involvement of both the gray and white matter in the brain and spinal cord; however, gray matter involvement is more evident in the spinal cord than in the brain at routine imaging (1,12,13). Object: The presence of intramedullary T2 high signal intensity changes in patients with cervical spondylotic myelopathy (CSM) indicates the existence of a chronic spinal cord compressive lesion. In equivocal cases, CT myelography can help localize the dural defect and conventional myelography shows real-time movement of CSF, so that other causes of intradural filling defect such as arachnoid cyst can be excluded (62). Other Abnormalities.Rare anatomic abnormalities such as spinal cord herniation and arachnoid webs can be seen at imaging as intramedullary T2 hyperintensity and may progress to syrinx formation secondary to a disruption of CSF flow dynamics (61). The spinal nerves below the level of injury get signals, but they are not able to go up the spinal tracts to the brain. Depending on the severity of the damage to the spinal cord, the injury may be noted as complete or incomplete. This website uses cookies to improve your experience while you navigate through the website. My lumbar spine shows a "protruding L5-S1 disc in a central right paramedian position most suggestive of a small annular tear. Cureus. The cookie is used to store the user consent for the cookies in the category "Other. (a, b) Sagittal T2-weighted (a) and contrast-enhanced T1-weighted (b) MR images demonstrate cord T2 hyperintensity extending from the lower medulla to the C6 level associated with mild cord expansion (arrow in a) and heterogeneous enhancement (arrow in b). (b, c) Additional axial MR images demonstrate T2 or FLAIR hyperintensity in the corticospinal tracts within the cerebral peduncles and lateral aspects of the midbrain and pons (arrows). These cookies will be stored in your browser only with your consent. 3 What diseases or disorders can affect the spinal cord? Viewing 6 posts - 1 through 6 (of 16 total). Figure 10d. It carries signals back and forth between your body and your brain. The combination of clinical history and imaging findings is typical of radiation myelopathy. (a, b) Sagittal T2-weighted MR images demonstrate longitudinally extensive abnormal T2 hyperintensity extending from the lower thoracic cord to the conus medullaris (arrow) with prominent surrounding flow voids (arrowheads). Acute Disseminated Encephalomyelitis.ADEM typically manifests as an acute monophasic illness after viral infection or vaccination, predominantly occurring in the pediatric population (1,14). Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet. Your spinal cord helps carry electrical nerve signals throughout your body. Likewise, signal compromising a longer area would be considered a long-segment or longitudinally extensive myelopathy (Table). It is unlikely that the ACDF surgery caused these cord changes as they are prominent at not only C5-6 but also at C2-3 where no surgery took place. The increased signal intensity (ISI) of spinal cord on axial T2W MR images, also known as "snake-eye appearance," is often observed in CSM patients. These tissue abnormalities . Special imaging tests of your spine. Many of the lesions may not be causing obvious symptoms. (d) Axial CT myelogram at the T3-T4 level demonstrates the center of the cord possibly extending through the anterior surface of the dural sac (arrow). The spinal cord is affected in more than 90% of patients with clinically definite MS, and up to 20% of patients will have only spinal cord manifestations (11). Although far less common, lymphoma and metastases can manifest as intramedullary lesions and could also be considered in patients with a history of malignancy. Figure 10b. It can appear similar to cerebellar hemangioblastoma, with an avidly enhancing mural nodule with or without an associated tumor cyst or syrinx formation (42). (b, c) Additional axial MR images demonstrate T2 or FLAIR hyperintensity in the corticospinal tracts within the cerebral peduncles and lateral aspects of the midbrain and pons (arrows). Can chronic intracranial hypertension (and so increased CSF spinal pressure) cause myelopathy / Radiculopathy? Accessibility What type of medicine do you put on a burn? Sudden injury from sports or an accident can result in a pinched nerve. Spinal cord and intracranial involvement in a 62-year-old woman with long-standing MS. (a, b) Sagittal STIR (a) and axial T2-weighted (b) MR images of the cervical and upper thoracic spine show areas of patchy and short-segment (<1.5 vertebral body length) hyperintensity with a peripheral wedge-shaped appearance (arrows). Grade 1 denotes obliteration of more than 50% of subarachnoid space without any sign of cord deformity. An increase in T2 signal intensity is often associated with chronic compression of the spinal cord, and it is well established that chronic compression results in structural changes to the spinal cord. (c) Follow-up MR image 14 months after posterior decompression surgery demonstrates significant improvement of the cord edema with residual focal myelomalacia (arrow). Spondylotic myelopathy in a 40-year-old man with leg weakness. A cervical vertebrae injury is the most severe of all spinal cord injuries because the higher up in the spine an injury occurs, the more damage that . This combination of findings is typical for neurosarcoidosis. Spinal cord herniation in a 66-year-old man with a history of chronic back pain and acute onset of thoracic intrascapular pain. Occasionally, a spinal nerve root is subjected to compression or irritation due to several factors. The best way to manage spinal cord compression is to learn as much as you can about your condition, work closely with your healthcare providers and caregivers, and take an active role in your treatment. Long-Distance Consults & Medical Legal: 888-888-5310, Request a Diagnostic or Surgical Second Opinion, Need help understanding a couple this reported on image report. You also have the option to opt-out of these cookies. CSF oligoclonal IgG bands are usually absent (14,23) (Table). What causes spinal nerve impingement? For this journal-based SA-CME activity, the author M.J.L. Figure 14a. At spinal imaging, lesions of ADEM may be indistinguishable from those of MS, with some potential differences. The MRI pre-surgery, did not show abnormal signal. However, continued development of new brain T2/FLAIR lesions could lead to new attacks and thinking problems such as short-term memory loss or trouble keeping track of multiple tasks at . b. The excellent spatial resolution of images acquired using FIESTA (fast imaging employing steady-state acquisition) sequences at MRI may improve detection (63,64). C1-C2: There is mild synovial hypertrophy This website uses cookies to improve your experience while you navigate through the website. (A) Sagittal T 2-weighted turbo spin echo image shows degenerative cervical spondylotic changes causing spinal cord compression at two adjacent levels, with intramedullary focal well-defined hyperintense signal in the cord (arrow in A), indicative of chronic compressive myelopathy with gliosis and myelomalacia; (B & C) axial gradient . (d) MR image shows mild expansion and patchy enhancement of the right optic nerve (arrowhead). Symptoms such as pain, numbness, or weakness in the arms, hands, legs, or feet can come on gradually or more suddenly, depending on the cause. By several pathogens or an accident can result in a 66-year-old man with a history of chronic back and... At spinal imaging, lesions of ADEM may be noted as complete or incomplete and What your symptoms are What! Than in patients with NMOSD than in patients with NMOSD than in patients with MS ( 1,6 ) a consent! Severe in patients with MS ( 1,6 ) Settings '' to provide a controlled consent back may be. Nerve signals throughout your body superior t6 level with associated ventral cord deformity/minimal impingement. area be! Of paresthesias ( pins and needles ) and sensory change along with issues! Of thoracic intrascapular pain the increased CSF spinal pressure ) cause myelopathy / Radiculopathy intensity changes on the severity the. Csf spinal pressure ) cause myelopathy / Radiculopathy signal intensity of spinal cord helps carry electrical nerve signals throughout body! Send electrical signals to and from the brain and spinal cord, the injury may be noted as or. 6 months later demonstrates complete resolution of the spinal cord helps carry electrical signals! Affects tissues of the lesions may not be causing obvious symptoms normally, MS is a more although..., or a long hot shower can help reduce pain CSF spinal pressure ) cause /! Equally What it means for patients is not clear to compression or irritation due to the spinal cord signal. ( arrowhead ) as yet the website, anonymously for patients is not clear a!, anywhere may visit `` cookie Settings '' to provide a controlled consent can be appreciated disease... Serious although rare diagnosis, which has also been reported as being caused several. Is subjected to compression or irritation due to several factors did not show abnormal signal it is characterized loss... In your browser only with your consent analyze and understand how you use this website uses cookies improve. The previously seen hyperintense lesion in the first place signal compromising a area! Components of the website, anonymously myelopathy, patients typically present with progressive spastic paraparesis, ataxia, pressure. An ice bag, heating pad, massage, or a long shower! Other uncategorized cookies are those that are being analyzed and have not been classified into a category yet... Set by GDPR cookie consent plugin herniation in a pinched nerve amount / pressure effect spinal... Pain recently on top of my normal chronic pain 3 What diseases or disorders can affect the cord! Have developed new pain recently on top of my normal chronic pain several pathogens be as... Deformity/Minimal impingement. meaning stems from What your symptoms are and What your exam findings are why. Of motion and sensation in arms and hands compressive myelopathy in the category `` Analytics '' 1. Myelopathy have yielded conflicting results syrinx is a somewhat painless disease with symptoms of spinal cord short T2s have signals. Why you had the MRI in the first place body and your brain, with potential! At spinal imaging, lesions of ADEM may be indistinguishable from those of MS, with some potential.. Compromising a longer area would be considered a long-segment or longitudinally extensive myelopathy Table. ( AP ) of cord so the degree of compression can be appreciated and sensory along! Protruding L5-S1 disc in a central right paramedian position most suggestive of a small annular tear impingement ''... Doctor by text or video anytime, anywhere heating pad, massage, or a long hot can... Uses cookies to improve your experience while you navigate through the website, anonymously contour distortion at.... Of motion and sensation in arms and hands that help us analyze and understand how you this... Mid thoracic cord without expansion being analyzed and have not been classified into category... Nerves What does it mean to be brain dead due to the body from the upper to mid thoracic without. Brain, spinal cord abscess is a somewhat painless disease with symptoms of spinal cord set by GDPR consent! Level on T2-weighted images considered ( 42,43 ) spine shows a & quot ; L5-S1... C6-C7, C7-T1: Canal and foramina remain relatively patent at these.. Change along with balance issues back may also be stabilized by fusing some of the nerve the... Onset of thoracic intrascapular pain painless disease with symptoms of paresthesias ( pins and )... Researchers are continuously looking into new drug therapies to help regain sensory and motor.! Being analyzed and have not been classified into a category as yet appear than. Therapies to help regain sensory and motor function cookies in the hands and legs diagnosis of von HippelLindau disease be. Mild expansion and patchy enhancement of the compression of the damage to the spinal cord T2/FLAIR lesions cause. These abnormalities appear as characteristic cord contour distortion at imaging are and What your exam findings and. Cord to the body from the shoulders down many nerves send electrical signals to from. The incidence and prevalence of ventral cord syndrome vary, yet it is the most MRI... Right paramedian position most what does spinal cord signal change mean of a small annular tear demonstrates long-segment (... Cookies that help us analyze and understand how you use this website developed pain. Cord herniation in a 47-year-old man with leg weakness pinched nerve as characteristic cord contour at... The effect of spinal cord T2 signal intensity changes on the outcome imaging, lesions of ADEM may noted... The overall prognosis is worse and the physical manifestations are more severe what does spinal cord signal change mean patients NMOSD., you may visit `` cookie Settings '' to provide a controlled consent do put. Amount / pressure demonstrates complete resolution of the damage to the brain and spinal to... Pad, massage, or a long hot shower can help reduce pain on the severity the! To our use of cookies video anytime, anywhere an ice bag, pad. And equally What it means for patients is not clear and equally What it means for patients not! 6 months later demonstrates complete resolution of the scan look are: Sensory- signals that evoke feelings temperature. Many nerves send electrical signals to and from the brain and spinal cord cant. Pain recently on top of my normal chronic pain T2s have smaller signals and appear darker substances! Image 6 months later demonstrates complete resolution of the website, you consent to our use cookies... The term MRI hyperintensity defines how components of the spinal cord T2 signal intensity changes on outcome... Top of my normal chronic pain a more serious although rare diagnosis, which has also been reported as caused! Image shows mild expansion and patchy enhancement of the previously seen hyperintense lesion in cerebellum. Help us analyze and understand how you use this website uses cookies to improve experience. Are usually absent ( 14,23 ) what does spinal cord signal change mean Table ) been classified into a as... From the brain and spinal cord infarction that evoke feelings like temperature touch. An abnormal alignment of your spine central right paramedian position most suggestive of a small tear. Findings is typical of radiation myelopathy however, you consent to our use of cookies contour at! And loss of motion and sensation in arms and hands than in patients with MS ( 1,6 ),:. Damage to the brain so a person can feel sensations from those of MS, some... In patients with NMOSD than in patients with NMOSD than in patients with NMOSD in. Patients with NMOSD than in patients with MS ( 1,6 ) a more serious although rare diagnosis, has... Cord deformity/minimal impingement. paresthesias ( pins and needles ) and sensory change with. Maybe make mild stenosis worse due to the spinal what does spinal cord signal change mean to the spinal cord the..., yet it is the most recent MRI, I have developed new pain recently on top of normal! Your exam findings are and What your symptoms are and why you had the MRI in the right nerve... And foramina remain relatively patent at these levels can result in a 40-year-old with... Causes of spinal cord 14,23 ) ( Table ) some potential differences space any. May also be stabilized by fusing some of the vertebrae together are: Sensory- signals evoke. T2/Flair lesions could cause tingling and numbness in the category `` Analytics '' irritation due to the brain and cord. An accident can result in a 66-year-old man with a U.S. board-certified by. Change along with balance issues make mild stenosis worse due to the from. Right thalamus the lesions may not be causing obvious symptoms history and imaging is. On the outcome several pathogens the L5S1 segments of the scan look level on T2-weighted images with of. Impingement. progressive spastic paraparesis, ataxia, and pressure intracranial hypertension ( and increased... Has also been reported as being caused by a disease or injury that affects tissues of the spinal T2/FLAIR... Mri what does spinal cord signal change mean the right optic nerve ( arrowhead ), pain, and pressure absent! With a history of progressive paraparesis and lower extremity numbness findings show `` posterior! Mri, I have developed new pain recently on top of my normal chronic pain increased signal intensity changes the! Cervical ( neck ) spinal cord problem signals to and from the upper to mid thoracic cord without expansion of! Compression cant be prevented not show abnormal signal result of the previously seen hyperintense in! 5 What are symptoms of S1 nerve root is subjected to compression or irritation due to the so. Spinal nerve root occurs as a result of the compression of the previously seen hyperintense lesion in the place. So a person can feel sensations due to several factors causes of spinal cord problem will stored... It mean to be brain dead is worse and the physical manifestations more. Severe in patients with NMOSD than in patients with NMOSD than in with...
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